Medical University  |  MUSC Hospital  |  Directory
Center for Drug and Alcohol Programs

About CDAP


Clinical Services

Basic Science Research

Clinical Trials


Recent Publications


Highlighted Events

In the News

Grand Rounds



Addiction Information

Community Outreach



CDAP Highlights (pdf)

Contact Us

ASD Intranet 



CDAP > Alcohol and Drug Addiction Information, Center for Drug and Alcohol Programs
Alcohol and Drug Addiction Information, Center for Drug and Alcohol Programs

Many people believe that addiction to alcohol and other drugs is a weakness or lack of willpower that is primarily a moral or character problem. Contrary to this popular opinion, scientific research, especially in the last 10 years, has convinced experts that addiction is definitely a disease of the brain. 

There is a major difference between addiction and simple use or abuse. People who use cocaine or drink alcohol too much can still exert control over their behavior. However, once they become addicted, their brains change in such a way that they cannot live without drugs or alcohol. At this point, they have lost the ability to say “No.”

Control is lost because the brain has changed in complex ways.  Addictive drugs such as alcohol, nicotine, and cocaine can affect the structure and function of the brain. Just like in an electrical system, drugs can change the circuits in the brain that control emotions and motivation, impairing an addicted person’s power of choice. With repeated heavy use, the structure and shape of brain cells and the connections between them change radically. The brains of addicts are very different than those of non-addicts.


CDAP In the News

Alcoholism is treatable in more than one way, according to a seven year study... Read More 

Of course, this doesn’t happen overnight. People begin using alcohol, nicotine or cocaine because these substances make them feel good. These drugs cause an increase in certain neurotransmitters (chemicals that communicate information between brain cells) that, in turn, produce feelings of euphoria and pleasure. Over time, with continued use, addictive drugs cause long-lasting changes in the brain’s pleasure and reward system. Chronic use of a drug to stimulate these neurotransmitters reduces the brain’s natural ability to produce pleasure without the drug. Then, when a person stops using drugs, he no longer can experience pleasure and may feel depressed and anxious. After a while, alcohol and drugs are needed just to feel “normal”.

Why doesn’t everyone who drinks, smokes or uses cocaine become addicted?  Vulnerability to addiction is affected by many factors. Genetic predisposition appears to be a major predisposing factor particularly with alcohol dependence. Children of alcoholics are 2 to 4 times more likely to become alcoholics or drug addicts and more than 60% of alcoholics have family histories of alcoholism. Genetics may especially play a role in early-onset alcoholism.

Additional Resources:

Do you have a drinking problem? Take our Alcohol Risk Assessment

Seeking Drug Abuse Treatment? Know What to Ask

Alcohol and Alcohol Dependence 

Frequently Asked Questions About Alcoholism 
Coping with Urges to Drink (Rethinking Drinking/NIAAA) 

Drugs, Brains, and Behavior: The Science of Addiction (NIDA) 

The Addiction Project (produced by HBO) 

Cocaine Addiction 

Nicotine Addiction (Smoking) 

Psychiatric Disorders and Addiction 

If you would like to be part of the solution to overcoming this destructive disease, donate to the Center for Drug and Alcohol Programs. (Please select "Center for Drug and Alcohol Programs" in the designation drop down box.)


Helpful Links

      CDAP Facebook  CDAP Twitter   

Online Giving

Participation in CDAP Research

"I felt at all times that the staff I encountered were very interested in helping me. I never felt like a 'number.' "-CEL

" I did not feel judged or less of a person because of my alcohol issues. It has been a very positive experience...I also now realize this is a forever problem that I have to address on a daily basis."-Bobby

"This was an excellent experience. I learned a lot about alcohol dependence, coping strategies and other health related issues as they involve alcohol consumption. Most importantly my personal and family life have improved dramatically. Thank you, thank you, thank you!" -James