Dr. Judson Chandler
Associate Professor, Department of Neurosciences
Associate Professor, Department of Psychiatry and Behavioral Sciences |
Research Interests Dr. Chandler’s research program is focused on understanding the fundamental processes that underlie the plasticity of the nervous system. In particular, his laboratory is investigating how the brain changes and adapts in response to environmental influences such as exposure to drugs of abuse and alcohol. It is widely believed that changes in glutamatergic neurotransmission mediate the neuroadaptive processes of addiction and tolerance. Areas of research interest include receptor trafficking and synaptic localization, signal transduction, and dendritic spine dynamics. Techniques being employed include cell culture, molecular and biochemical procedures, confocal and multiphoton imaging, and in vitro electrophysiology. Education | Birmingham Southern College, Birmingham, AL | B.S. | 1980 | Biology | | University of Texas, Austin, TX | Ph.D. | 1988 | Pharmacology | | University of Florida, Gainesville, GL | Postdoctoral | 1989 | Neuropharmacology |
Professional Experience | 1980-1982 | Research Assistant, Department of Pharmacology, University of Alabama, Birmingham, AL | | 1983-1987 | Graduate Student, Department of Pharmacology & Toxicology, College of Pharmacy, University of Texas, Austin, TX | | 1988-1989 | Postdoctoral Fellow, Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL | | 1989-1994 | Assistant Research Scientist, Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL | | 1994-1999 | Assistant Professor, Department of Pharmacology & Therapeutics, Louisiana State University Medical Center, Shreveport, LA | | 1999 | Associate Professor, Department of Pharmacology &Therapeutics, Louisiana State University Medical Center, Shreveport, LA | | 1999-present | Associate Professor, Department of Neurosciences and Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC |
Awards and Honors | 1989 | Postdoctoral Training Fellowship, National Institute on Aging | | 1989 | International Society of Neurochemistry Young Scientist Travel Award | | 1990-1995 | NIAAA K21 Scientist Development Award | | 1991 | International Society of Neurochemistry Young Scientist Travel Award | | 1998-2004 | Research Society on Alcoholism Education Committee | | 1999-present | Board of Reviewing Editors; Alcoholism: Clinical and Experimental Research | | 2001-present | NIAAA Special Emphasis Study Section (AA-1) |
Recent Publications
Kroener S, Chandler LJ, Phillips PE & Seamans JK. Dopamine modulates persistent synaptic activity and enhances the signal-to-noise ratio in the prefrontal cortex. PloS One 4(8):e6507, 2009. PMCID: PMC2715878 Mulholland PJ, Carpenter-Hyland EP, Woodward JJ & Chandler LJ. Ethanol disrupts NMDA receptor and astroglial EAAT2 modulation of Kv2.1 potassium channels in hippocampus. Alcohol 43(1):45-50, 2009. PMCID: PMC2674284 Mulholland PJ, Hopf FW, Bukiya AN, Martin GE, Liu J, Dopico AM, Bonci A, Treistman SN & Chandler LJ. Sizing up ethanol-induced plasticity: The role of small and large conductance calcium-activated potassium channels. Alcoholism: Clinical and Experimental Research 33(7):1125-1135, 2009. PMCID: PMC2760381 Abernathy K, Chandler LJ & Woodward JJ. Alcohol and the prefrontal cortex. International Review of Neurobiology 91:289-320, 2010. Mulholland PJ & Chandler LJ. Inhibition of glutamate transporters couples to Kv4.2 dephosphorylation through activation of extrasynaptic NMDA receptors. Neuroscience 165(1):130-137, 2010. PMCID: PMC2787836 Mulholland PJ, Becker HC, Woodward JJ & Chandler LJ. Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses. Biological Psychiatry 69(7):625-632, 2011. PMCID: PMC3103782 |
