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CDAP > Basic Science Researchers > Dr. Judson Chandler
Dr. Judson Chandler

Dr. Judson Chandler

Associate Professor, Department of Neurosciences
Associate Professor, Department of Psychiatry and Behavioral Sciences



Research Interests

Dr. Chandler’s research program is focused on understanding the fundamental processes that underlie the plasticity of the nervous system. In particular, his laboratory is investigating how the brain changes and adapts in response to environmental influences such as exposure to drugs of abuse and alcohol. It is widely believed that changes in glutamatergic neurotransmission mediate the neuroadaptive processes of addiction and tolerance. Areas of research interest include receptor trafficking and synaptic localization, signal transduction, and dendritic spine dynamics. Techniques being employed include cell culture, molecular and biochemical procedures, confocal and multiphoton imaging, and in vitro electrophysiology.


Birmingham Southern College, Birmingham, AL B.S.  1980Biology  
University of Texas, Austin, TXPh.D. 1988    Pharmacology 
University of Florida, Gainesville, GLPostdoctoral1989Neuropharmacology 

Professional Experience

1980-1982 Research Assistant, Department of Pharmacology, University of Alabama, Birmingham, AL
1983-1987Graduate Student, Department of Pharmacology & Toxicology, College of Pharmacy, University of Texas, Austin, TX
1988-1989Postdoctoral Fellow, Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL
1989-1994Assistant Research Scientist, Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL
1994-1999Assistant Professor, Department of Pharmacology & Therapeutics, Louisiana State University Medical Center, Shreveport, LA
1999Associate Professor, Department of Pharmacology &Therapeutics, Louisiana State University Medical Center, Shreveport, LA
1999-presentAssociate Professor, Department of  Neurosciences and Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC

Awards and Honors

1989Postdoctoral Training Fellowship, National Institute on Aging 
1989International Society of Neurochemistry Young Scientist Travel Award
1990-1995 NIAAA K21 Scientist Development Award
1991International Society of Neurochemistry Young Scientist Travel Award
1998-2004Research Society on Alcoholism Education Committee
1999-present Board of Reviewing Editors; Alcoholism: Clinical and Experimental Research
2001-presentNIAAA Special Emphasis Study Section (AA-1)

Recent Publications

Gorelova N, Mulholland PJ, Chandler LJ & Seamans JK. The glutamatergic component of the mesocortical pathway emanating from different subregions of the ventral midbrain. Cerebral Cortex 22(2):327-336, 2012. PMCID: 3256405

Kroener S, Mulholland PJ, New NN, Gass JT, Becker HC & Chandler LJ. Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex. PLoS One 7(5):e37541, 2012. PMCID: 3364267

Mulholland PJ, Jordan BA & Chandler LJ. Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons. Alcohol 46(6):569-576, 2012. PMCID: 3411901

Gass JT & Chandler LJ. The plasticity of extinction: contribution of the prefrontal cortex in treating addiction through inhibitory learning. Frontiers in Psychiatry 4:46, 2013. PMCID: 3667556

Jung Y, Mulholland PJ, Wiseman SL, Judson Chandler L & Picciotto MR. Constitutive knockout of the membrane cytoskeleton protein beta adducin decreases mushroom spine density in the nucleus accumbens but does not prevent spine remodeling in response to cocaine. European Journal of Neuroscience 37(1):1-9, 2013. PMCID: 3538958


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