Dr. Judson Chandler
Associate Professor, Department of Neurosciences
Associate Professor, Department of Psychiatry and Behavioral Sciences |
Research Interests Dr. Chandler’s research program is focused on understanding the fundamental processes that underlie the plasticity of the nervous system. In particular, his laboratory is investigating how the brain changes and adapts in response to environmental influences such as exposure to drugs of abuse and alcohol. It is widely believed that changes in glutamatergic neurotransmission mediate the neuroadaptive processes of addiction and tolerance. Areas of research interest include receptor trafficking and synaptic localization, signal transduction, and dendritic spine dynamics. Techniques being employed include cell culture, molecular and biochemical procedures, confocal and multiphoton imaging, and in vitro electrophysiology. Education | Birmingham Southern College, Birmingham, AL | B.S. | 1980 | Biology | | University of Texas, Austin, TX | Ph.D. | 1988 | Pharmacology | | University of Florida, Gainesville, GL | Postdoctoral | 1989 | Neuropharmacology |
Professional Experience | 1980-1982 | Research Assistant, Department of Pharmacology, University of Alabama, Birmingham, AL | | 1983-1987 | Graduate Student, Department of Pharmacology & Toxicology, College of Pharmacy, University of Texas, Austin, TX | | 1988-1989 | Postdoctoral Fellow, Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL | | 1989-1994 | Assistant Research Scientist, Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL | | 1994-1999 | Assistant Professor, Department of Pharmacology & Therapeutics, Louisiana State University Medical Center, Shreveport, LA | | 1999 | Associate Professor, Department of Pharmacology &Therapeutics, Louisiana State University Medical Center, Shreveport, LA | | 1999-present | Associate Professor, Department of Neurosciences and Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC |
Awards and Honors | 1989 | Postdoctoral Training Fellowship, National Institute on Aging | | 1989 | International Society of Neurochemistry Young Scientist Travel Award | | 1990-1995 | NIAAA K21 Scientist Development Award | | 1991 | International Society of Neurochemistry Young Scientist Travel Award | | 1998-2004 | Research Society on Alcoholism Education Committee | | 1999-present | Board of Reviewing Editors; Alcoholism: Clinical and Experimental Research | | 2001-present | NIAAA Special Emphasis Study Section (AA-1) |
Recent Publications
Hu W, Lu T, Chen A, Huang Y, Hansen R, Chandler LJ & Zhang HT. Inhibition of phosphodiesterase-4 decreases ethanol intake in mice. Psychopharmacology 218(2):331-339, 2011.
Mulholland PJ, Becker HC, Woodward JJ & Chandler LJ. Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses. Biological Psychiatry 69(7):625-632, 2011. PMCID: 3103782 Gorelova N, Mulholland PJ, Chandler LJ & Seamans JK. The glutamatergic component of the mesocortical pathway emanating from different subregions of the ventral midbrain. Cerebral Cortex 22(2):327-336, 2012. PMCID: 3256405 Kroener S, Mulholland PJ, New NN, Gass JT, Becker HC & Chandler LJ. Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex. PLoS One 7(5):e37541, 2012. PMCID: 3364267 Mulholland PJ, Jordan BA & Chandler LJ. Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons. Alcohol 46(6):569-576, 2012. PMCID: 3411901
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