Dr. Peter Kalivas
Distinguished University Professor
Professor and Co-Chair, Department of Neurosciences
Professor, Department of Psychiatry and Behavioral Sciences |
Research Interests The Kalivas lab studies neuroplasticity underlying the development of addiction to drugs of abuse. Research is at the level of protein biochemistry, neural circuitry, and dendritic spine morphology, as well as behavioral modeling. The current focus is in adaptations in excitatory neurotransmission and elucidating the fundamental role of extracellular glutamate homeostasis in regulating neurotransmission and neuroplasticity. This has led to preclinical and clinical evaluations of specific proteins as targets in treating addiction, including metabotropic glutamate receptors and the cystine-glutamate exchanger. Education | Western Washington State University, Bellingham, WA | B.S. | 1974 | Biology | | University of Washington, Seattle, WA | Ph.D. | 1980 | Pharmacology | | University of North Carolina, Chapel Hill, NC | Postdoctoral | 1982 | Neuropharmacology |
Professional Experience | 1982-1984 | Assistant Professor, Pharmacology, Louisiana State University Medical Center, New Orleans, LA | | 1984-1987 | Assistant Professor, Department of Comparative Anatomy, Pharmacology, & Physiology, Washington State University, Pullman, WA | | 1987-1991 | Associate Professor, Department of Comparative Anatomy, Pharmacology, & Physiology, Washington State University, Pullman, WA | | 1990-1998 | Director, Alcohol and Drug Abuse Program, Washington State University, Pullman, WA
| | 1991-1998 | Professor, Department of Comparative Anatomy, Pharmacology, & Physiology, Washington State University, Pullman, WA | | 1995-1996 | Visiting Professor, Department of Anatomy & Histology, The Flinders University School of Medicine, Adelaide, SA, Australia | | 1998-present | Professor and Chair, Department of Neurosciences, MUSC, Charleston, SC
| | 2000-2003 | Co-Director, Neuroscience Institute, MUSC, Charleston, SC |
Awards and Honors | 1980 | NIMH Postdoctoral Trainee Fellowship | | 1990 | NIDA Research Career Development Award | | 1993 | Smith-Kline-Beecham Research Excellence Award | | 1993 | Plenary Lecture, Summer Neuropeptide Conference, Martha's Vineyard | | 1995 | Fogarty Senior Fellowship | | 1995 | Plenary Lecture, Dopamine Symposium, Taipei, Taiwan | | 1996 | Daniel H Efron Award (American College of Neuropsychopharmacology) | | 1996 | Washington State Sahlin Faculty Research Excellence Award | | 1996 | Plenary Lecture, 7th In Vivo Monitoring of Molecules in Neuroscience, Tenerife, Spain | | 1996 | Grass Traveling Scientist Award, Indianapolis Chapter of Society for Neuroscience, Indianapolis | | 1998 | Elliot Stellar Lecture, University of Pennsylvania, Philadelphia, PA | | 1999 | Grass Traveling Scientist Award, Nashville Chapter of Society for Neuroscience, Nashville, TN | | 1999 | Plenary Lecture, American Neuropsychiatric Society, Fort Myers, FL | | 1999 | Grass Traveling Scientist Award, Mississippi Chapter of Society for Neuroscience, Jackson | | 2001 | Honorary Professor of Neurological Sciences, Nanjing Medical University, China | | 2001 | Grass Traveling Scientist Award, Kentucky Chapter of Society for Neuroscience, Lexington, KY | | 2001 | Plenary Lecture, Neuroscience Hellenic Society, San Diego, CA | | 2001-2011 | NIDA Merit Award for 2001-2011
| | 2002 | Wheeler Plenary Speaker, 33rd International Narcotics Research Conference, Pacific Grove | | 2002 | Plenary Lecture, Society for Neuroimmunology, Tampa, FL | | 2002 | Appointed to the National Advisory Council on Drug Abuse | | 2003 | Distinguished University Professor, MUSC | | 2003 | Grass Traveling Scientist Award, Michigan Chapter Society for Neuroscience, Detroit, MI | | 2003 | Appointed to NARSAD Scientific Advisory Board | | 2003 | Appointed to the Fundacion Cerebro y Mente Advisory Board | | 2004 | Keynote Lecture, University of Cincinnati Medical School 25th Annual Research Forum | | 2004 | Sigma Xi Banquet Speaker, The Citadel, Charleston, SC | | 2005 | Distinguished Basic Science Scholar on the Addictions (Am J Addict) | | 2005 | Plenary Speaker, Research Society for Alcoholism, Santa Barbara, CA | | 2005 | Elected to ACNP Council | | 2005 | Appointed as Chair of the NIDA Medications Development SAB | | 2006 | Plenary Lecture, International Neuroscience Winter Conference, Solden, Austria | | 2006 | Special Lecture, Society for Neuroscience Meeting, Atlanta, GA |
Recent Publications
Brown TE, Lee BR, Mu P, Ferguson D, Dietz D, Ohnishi YN, Lin Y, Suska A, Ishikawa M, Huang YH, Shen H, Kalivas PW, Sorg BA, Zukin RS, Nestler EJ, Dong Y & Schluter OM. A silent synapse-based mechanism for cocaine-induced locomotor sensitization. Journal of Neuroscience 31(22):8163-8174, 2011. Cramer SC, Sur M, Dobkin BH, O'Brien C, Sanger TD, Trojanowski JQ, Rumsey JM, Hicks R, Cameron J, Chen D, Chen WG, Cohen LG, deCharms C, Duffy CJ, Eden GF, Fetz EE, Filart R, Freund M, Grant SJ, Haber S, Kalivas PW, Kolb B, Kramer AF, Lynch M, Mayberg HS, McQuillen PS, Nitkin R, Pascual-Leone A, Reuter-Lorenz P, Schiff N, Sharma A, Shekim L, Stryker M, Sullivan EV & Vinogradov S. Harnessing neuroplasticity for clinical applications. Brain 134(Pt 6):1591-1609, 2011. PMCID: PMC3102236 Mohan A, Pendyam S, Kalivas PW & Nair SS. Molecular diffusion model of neurotransmitter homeostasis around synapses supporting gradients. Neural Computation 23(4):984-1014, 2011. Moussawi K, Zhou W, Shen H, Reichel CM, See RE, Carr DB & Kalivas PW. Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. Proceedings of the National Academy of Sciences 108(1):385-390, 2011. PMCID: PMC3017187 Reichel CM, Moussawi K, Do PH, Kalivas PW & See RE. Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking. Journal of Pharmacology and Experimental Therapeutics 337(2):487-493, 2011. PMCID: PMC3083102 Reissner KJ, Uys JD, Schwacke JH, Comte-Walters S, Rutherford-Bethard JL, Dunn TE, Blumer JB, Schey KL & Kalivas PW. AKAP signaling in reinstated cocaine seeking revealed by iTRAQ proteomic analysis. Journal of Neuroscience 31(15):5648-5658, 2011. Steketee JD & Kalivas PW. Drug wanting: Behavioral sensitization and relapse to drug-seeking behavior. Pharmacological Reviews 63(2):348-365, 2011. PMCID: PMC3082449
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