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CDAP > Basic Science Researchers > Dr. Jacqueline F. McGinty
Dr. Jacqueline F. McGinty

Dr. Jacqueline F. McGinty

Professor, Department of Neurosciences
Professor, Department of Psychiatry and Behavioral Sciences
Associate Dean, College of Graduate Studies



Research Interests

Dr. McGinty’s research focuses on the effects of drugs of abuse on neurotransmitter release and gene expression in the rat brain and the effects of methamphetamine neurotoxicity in neurotrophic factor knockout mice during aging.  Currently Dr. McGinty is using cDNA microarray technology, in situ hybridization, immunoblotting, and immunohistochemistry to characterize changes in gene expression that may signify longterm neuroadaptations in the brain thought to underlie drug and alcohol addiction and neurotoxicity during aging. 


Connecticut College, New London, CTB.A. 1972Psychology 
Downstate Medical Center SUNY, Brooklyn, NY  Ph.D. 1978Neuroanatomy
The Salk Institute, LaJolla, CAResident Associate1982Neuropharmacology

Professional Experience

1982-1983Asst. Research Neuroscientist, Department of Neurosciences School of Medicine U. California, San Diego, La Jolla, California
1983-1988Asst. Professor, Department of Anatomy East Carolina U. Sch. Med. Greenville, NC
1988-1993Assoc. Professor, Department of Anatomy & Cell Biology East Carolina U. Sch. Med. Greenville, NC       
1993-1999Professor, Department of Anatomy & Cell Biology East Carolina U. Sch. Med. Greenville, NC       
1999-presentProfessor, Department of Neurosciences, MUSC, Charleston, SC
2003-presentAssociate Dean, College of Graduate Studies, MUSC, Charleston, SC
2005-presentProfessor, Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC

Awards and Honors

1978Member, New York Academy of Sciences
1978Member, Society for Neuroscience
1986Member, International Brain Research Organization
1986-1989Council member North Carolina Chapter of the Society for Neuroscience
1987INSERM Visiting Scientist Fellowship U. Grenoble, Grenoble France
1990-1991President, North Carolina Chapter of the Society for Neuroscience
1990-1996Member of Drug Abuse Biomedical Review Committee 3, NIDA
1990-1999Eastern Carolina Chapter of the Society for Neuroscience
1992Grass Traveling Scientist, New Orleans Chapter of the Society for Neuroscience
1999-2001SC Chapter of the Society for Neuroscience Board
2001-2005Member of NIH Biomedical Review IFCN-1
2003-2005Chair of NIH Biomedical Review committee Neurobiology of Motivated Behavior (formerly IFCN-1)

Recent Publications

Littrell OM, Pomerleau F, Huettl P, Surgener S, McGinty JF, Middaugh LD, Granholm AC, Gerhardt GA & Boger HA. Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice. Neurobiology of Aging 33(2):427, e421-414, 2012. PMCID: 3117013

McGinty JF. The many faces of MeCP2. Neuropsychopharmacology 37(2):313-314, 2012. PMCID: 3242321

Melendez RI, McGinty JF, Kalivas PW & Becker HC. Brain region-specific gene expression changes after chronic intermittent ethanol exposure and early withdrawal in C57BL/6J mice. Addiction Biology 17(2):351-364, 2012.

Reichel CM, Ramsey LA, Schwendt M, McGinty JF & See RE. Methamphetamine-induced changes in the object recognition memory circuit. Neuropharmacology 62(2):1119-1126, 2012. PMCID: 3262904

Schwendt M, Sigmon SA & McGinty JF. RGS4 overexpression in the rat dorsal striatum modulates mGluR5- and amphetamine-mediated behavior and signaling. Psychopharmacology (Berl) 221(4):621-635, 2012.

Schmidt HD, McGinty JF, West AE & Sadri-Vakili G. Epigenetics and psychostimulant addiction. Cold Spring Harbor Perspectives in Medicine 3(3):a012047, 2013.


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