Dr. Larry Middaugh
Professor Emeritus, Department of Psychiatry and Behavioral Sciences
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Research Interests Dr Middaugh’s current research interests include assessing the effects of ethanol on the stimulative, discriminative, and rewarding effects of methylphenidate using a murine model; determining the interactive effects of genetic reductions in brain- or glia-derived neurotrophic factors and prenatal inflammation on the aging-related decline of motor function and dopamine neurotransmitter systems utilizing genetically manipulated mice; and examining the role of organic cation transporters transport of amphetamine and methylphenidate and their effects on motor stimulation and neurotransmitter release also using genetically manipulated mice. Dr. Middaugh’s research also focuses on characterizing the influence of chronic ethanol exposure on ethanol consumption and its effects on glutamate and dopamine neurotransmitter systems. Education | University of Kansas, Lawrence, KS | B.A. | 1961 | Psychology | | University of Kansas, Lawrence, KS | M.S. | 1966 | Psychology | | University of Tennessee, Knoxville, TN | Ph.D. | 1970 | Psychology/Physiology |
Professional Experience | 1970-1972 | Associate, Department of Biochemistry and Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC | | 1972-1977 | Assistant Professor, Department of Biochemistry and Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC | | 1977-1982 | Associate Professor, Department of Biochemistry, MUSC, Charleston, SC
| | 1981-1982 | Visiting Researcher, National Institute of Aging, Gerontology Research Center, Baltimore, Maryland | | 1988-2005 | Professor, Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC | | 2000-2005 | Professor, Department of Neurosciences, MUSC, Charleston, SC | | 2005-present | Professor Emeritus, Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC |
Awards and Honors
| 1979-present | NIAAA, NIEHA, NINDS Ad hoc | | 1981-1982 | Fellow, National Institute on Aging | | 1982-1988 | Editorial Advisory Board, Neurotoxicology and Teratology | | 1984-present | Member, Research Society on Alcoholism | | 1988-1992 | Member, Biomedical Research Review Committee Member, NIDA | | 1989-1992 | Editorial Advisory Board: Pharmacology Biochemistry and Behavior | | 1990-1997 | Editorial Advisory Board: Neurotoxicology Teratology | | 1997 | NIDA Center Grant Member | | 1999 | NIDA Center Grant Member | | 1999-2003 | Editorial Advisory Board: Neurotoxicology Teratology | | 2000 | NIDA Special Interest Panel Chair | | 2002 | NIAAA Medications Development Workshop | | 2005-2006 | NIDA-K |
Recent Publications
Boger HA, Granholm AC, McGinty JF & Middaugh LD. A dual-hit animal model for age-related parkinsonism. Progress in Neurobiology 90(2):217-229, 2010. Griffin WC, 3rd, Novak AJ, Middaugh LD & Patrick KS. The interactive effects of methylphenidate and ethanol on ethanol consumption and locomotor activity in mice. Pharmacology, Biochemistry, and Behavior 95(3):267-272, 2010. PMCID: PMC2862580 Boger HA, Mannangatti P, Samuvel DJ, Saylor AJ, Bender TS, McGinty JF, Fortress AM, Zaman V, Huang P, Middaugh LD, Randall PK, Jayanthi LD, Rohrer B, Helke KL, Granholm AC & Ramamoorthy S. Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes, Brain, and Behavior 10(2):186-198, 2011. PMCID: PMC3026906 Granholm AC, Zaman V, Godbee J, Smith M, Ramadan R, Umphlet C, Randall P, Bhat NR, Rohrer B, Middaugh LD & Boger HA. Prenatal LPS increases inflammation in the substantia nigra of GDNF heterozygous mice. Brain Pathology 21(3):330-348, 2011. PMCID: PMC3042034 McGovern RW, Middaugh LD, Patrick KS & Griffin WC, 3rd. The discriminative stimulus properties of methylphenidate in C57BL/6J mice. Behavioural Pharmacology 22:14-22, 2011. PMCID: PMC3099148 |
