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CDAP > Basic Science Researchers > Dr. John Woodward
Dr. John Woodward

Dr. John Woodward

Professor, Department of Neurosciences
Professor, Department of Psychiatry and Behavioral Sciences

Visit Dr. Woodward's Lab Web site: at http://www.musc.edu/~woodward

 

 

Research Interests

Dr. Woodward’s lab is focused on defining the neural sites of action of alcohol and abused inhalants such as toluene and TCE. Alcohol and abused inhalants produce diverse effects on neuronal function by altering the function of different types of ion channels that regulate neuronal excitability. These include voltage dependent channels as well as those gated by neurotransmitters such as glutamate, Ach and ATP. Electrophysiological recording techniques are used to directly measure the function of both recombinant and native channels while site-directed mutagenesis is used to probe for discrete sites of action on the ion channel itself.

Education 

Texas A&M University, College Station, TX  B.S.  1977  Fish Biology/Physiology
University of Washington, Seattle, WAM.S.1979Fish Biology/Physiology
University of Washington, Seattle, WAPh.D.1982Fish Biology/Physiology
University of Texas, Austin, TXPostdoctoral   1989Neuropharmacology

 Professional Experience

1982-1985  Post-Doctoral Research Associate, Division of Pharmacology, University of Texas, Austin, TX
1986-1989Lecturer and Research Scientist, Division of Pharmacology and Institute for Neurological Sciences, University of Texas, Austin, TX
1989-1994Assistant Professor, Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
1994-1999Associate Professor, Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
1999-2001Professor, Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
2001-presentProfessor, Department of  Neurosciences and Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC

Awards and Honors

1976   Phi Kappa Phi National Honor Society
1976-1977  University Undergraduate Research Fellow, Texas A&M University, College Station, TX
1981-1983University of Washington Egtvedt Scholarship for Academic Excellence, Seattle, WA
1985-1986National Research Service Award (NIMH), University of Texas at Austin, Austin, TX
1988-1989Nominated for Texas Excellence in Teaching Award
1991Outstanding Professor in Pharmacology/Toxicology, Virginia Commonwealth University, Richmond, VA
1998-2001NIAAA Study Section-AA1 Biomedical Research Review Subcommittee
1999Outstanding Professor in Pharmacology/Toxicology, Virginia Commonwealth University, Richmond, VA
2004-presentChair, NIH Study Section (Neurotoxicology and Alcohol;NAL), Chair 2006-2008

Recent Publications

Pava MJ, Blake EM, Green ST, Mizroch BJ, Mulholland PJ & Woodward JJ. Tolerance to cannabinoid-induced behaviors in mice treated chronically with ethanol. Psychopharmacology 219(1):137-147, 2012. PMCID: 3249519

Pava MJ & Woodward JJ. A review of the interactions between alcohol and the endocannabinoid system: implications for alcohol dependence and future directions for research. Alcohol 46(3):185-204, 2012. PMCID: 3327810

Woodward JJ & Pava M. Ethanol inhibition of up-states in prefrontal cortical neurons expressing the genetically encoded calcium indicator GCaMP3. Alcoholism, Clinical and Experimental Research 36(5):780-787, 2012. PMCID: 3297730

Xu M, Smothers CT, Trudell JR & Woodward JJ. Ethanol inhibition of constitutively open N-methyl-d-aspartate receptors. Journal of Pharmacology and Experimental Therapeutics 340(1):218-226, 2012. PMCID: 3251024

Badanich KA, Mulholland PJ, Beckley JT, Trantham-Davidson H & Woodward JJ. Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism. Neuropsychopharmacology 38(7):1176-1188, 2013. PMCID: 3656360

Beckley JT, Evins CE, Fedarovich H, Gilstrap MJ & Woodward JJ. Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons. Journal of Neuroscience 33(2):804-813, 2013. PMCID: 3542971

Hughes BA, Smothers CT & Woodward JJ. Dephosphorylation of GluN2B C-terminal tyrosine residues does not contribute to acute ethanol inhibition of recombinant NMDA receptors. Alcohol 47(3):181-186,

  

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