Dr. John Woodward
Professor, Department of Neurosciences
Professor, Department of Psychiatry and Behavioral Sciences |
Visit Dr. Woodward's Lab Web site: at http://www.musc.edu/~woodward Research Interests Dr. Woodward’s lab is focused on defining the neural sites of action of alcohol and abused inhalants such as toluene and TCE. Alcohol and abused inhalants produce diverse effects on neuronal function by altering the function of different types of ion channels that regulate neuronal excitability. These include voltage dependent channels as well as those gated by neurotransmitters such as glutamate, Ach and ATP. Electrophysiological recording techniques are used to directly measure the function of both recombinant and native channels while site-directed mutagenesis is used to probe for discrete sites of action on the ion channel itself. Education | Texas A&M University, College Station, TX | B.S. | 1977 | Fish Biology/Physiology | | University of Washington, Seattle, WA | M.S. | 1979 | Fish Biology/Physiology | | University of Washington, Seattle, WA | Ph.D. | 1982 | Fish Biology/Physiology | | University of Texas, Austin, TX | Postdoctoral | 1989 | Neuropharmacology |
Professional Experience | 1982-1985 | Post-Doctoral Research Associate, Division of Pharmacology, University of Texas, Austin, TX | | 1986-1989 | Lecturer and Research Scientist, Division of Pharmacology and Institute for Neurological Sciences, University of Texas, Austin, TX | | 1989-1994 | Assistant Professor, Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA | | 1994-1999 | Associate Professor, Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA | | 1999-2001 | Professor, Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA | | 2001-present | Professor, Department of Neurosciences and Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC |
Awards and Honors | 1976 | Phi Kappa Phi National Honor Society | | 1976-1977 | University Undergraduate Research Fellow, Texas A&M University, College Station, TX | | 1981-1983 | University of Washington Egtvedt Scholarship for Academic Excellence, Seattle, WA | | 1985-1986 | National Research Service Award (NIMH), University of Texas at Austin, Austin, TX | | 1988-1989 | Nominated for Texas Excellence in Teaching Award | | 1991 | Outstanding Professor in Pharmacology/Toxicology, Virginia Commonwealth University, Richmond, VA | | 1998-2001 | NIAAA Study Section-AA1 Biomedical Research Review Subcommittee | | 1999 | Outstanding Professor in Pharmacology/Toxicology, Virginia Commonwealth University, Richmond, VA | | 2004-present | Chair, NIH Study Section (Neurotoxicology and Alcohol;NAL), Chair 2006-2008
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Recent Publications
Mulholland PJ, Carpenter-Hyland EP, Woodward JJ & Chandler LJ. Ethanol disrupts NMDA receptor and astroglial EAAT2 modulation of Kv2.1 potassium channels in hippocampus. Alcohol 43(1):45-50, 2009. PMCID: PMC2674284 Sas AR, Bimonte-Nelson H, Smothers CT, Woodward J & Tyor WR. Interferon-alpha causes neuronal dysfunction in encephalitis. Journal of Neuroscience 29(12):3948-3955, 2009. Smothers CT & Woodward JJ. Expression of glycine-activated diheteromeric NR1/NR3 receptors in HEK293 cells is NR1 splice variant dependent. Journal of Pharmacology and Experimental Therapeutics 331(32) 2009. PMCID: PMC2784711 Sribnick EA, Del Re AM, Ray SK, Woodward JJ & Banik NL. Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels. Brain Research 1276:159-170, 2009. PMCID: PMC2700344 Woodward JJ & Pava MJ. Effects of ethanol on persistent activity and up-states in excitatory and inhibitory neurons in prefrontal cortex. Alcoholism: Clinical & Experimental Research 33(12):2134-2140, 2009. |
