Dr. John Woodward
Professor, Department of Neurosciences
Professor, Department of Psychiatry and Behavioral Sciences |
Visit Dr. Woodward's Lab Web site: at http://www.musc.edu/~woodward Research Interests Dr. Woodward’s lab is focused on defining the neural sites of action of alcohol and abused inhalants such as toluene and TCE. Alcohol and abused inhalants produce diverse effects on neuronal function by altering the function of different types of ion channels that regulate neuronal excitability. These include voltage dependent channels as well as those gated by neurotransmitters such as glutamate, Ach and ATP. Electrophysiological recording techniques are used to directly measure the function of both recombinant and native channels while site-directed mutagenesis is used to probe for discrete sites of action on the ion channel itself. Education | Texas A&M University, College Station, TX | B.S. | 1977 | Fish Biology/Physiology | | University of Washington, Seattle, WA | M.S. | 1979 | Fish Biology/Physiology | | University of Washington, Seattle, WA | Ph.D. | 1982 | Fish Biology/Physiology | | University of Texas, Austin, TX | Postdoctoral | 1989 | Neuropharmacology |
Professional Experience | 1982-1985 | Post-Doctoral Research Associate, Division of Pharmacology, University of Texas, Austin, TX | | 1986-1989 | Lecturer and Research Scientist, Division of Pharmacology and Institute for Neurological Sciences, University of Texas, Austin, TX | | 1989-1994 | Assistant Professor, Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA | | 1994-1999 | Associate Professor, Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA | | 1999-2001 | Professor, Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA | | 2001-present | Professor, Department of Neurosciences and Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC |
Awards and Honors | 1976 | Phi Kappa Phi National Honor Society | | 1976-1977 | University Undergraduate Research Fellow, Texas A&M University, College Station, TX | | 1981-1983 | University of Washington Egtvedt Scholarship for Academic Excellence, Seattle, WA | | 1985-1986 | National Research Service Award (NIMH), University of Texas at Austin, Austin, TX | | 1988-1989 | Nominated for Texas Excellence in Teaching Award | | 1991 | Outstanding Professor in Pharmacology/Toxicology, Virginia Commonwealth University, Richmond, VA | | 1998-2001 | NIAAA Study Section-AA1 Biomedical Research Review Subcommittee | | 1999 | Outstanding Professor in Pharmacology/Toxicology, Virginia Commonwealth University, Richmond, VA | | 2004-present | Chair, NIH Study Section (Neurotoxicology and Alcohol;NAL), Chair 2006-2008
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Recent Publications
Badanich KA, Becker HC & Woodward JJ. Effects of chronic intermittent ethanol exposure on orbitofrontal and medial prefrontal cortex-dependent behaviors in mice. Behavioral Neuroscience 125(6):879-891, 2011. PMCID: 3229192 Beckley JT & Woodward JJ. The abused inhalant toluene differentially modulates excitatory and inhibitory synaptic transmission in deep-layer neurons of the medial prefrontal cortex. Neuropsychopharmacology 36(7):1531-1542, 2011. PMCID: 3096820 Mulholland PJ, Becker HC, Woodward JJ & Chandler LJ. Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses. Biological Psychiatry 69(7):625-632, 2011. PMCID: 3103782 Xu M, Smothers CT & Woodward JJ. Effects of ethanol on phosphorylation site mutants of recombinant N-methyl-d-aspartate receptors. Alcohol 45(4):373-380, 2011. PMCID: 3095724 Pava MJ, Blake EM, Green ST, Mizroch BJ, Mulholland PJ & Woodward JJ. Tolerance to cannabinoid-induced behaviors in mice treated chronically with ethanol. Psychopharmacology 219(1):137-147, 2012. PMCID: 3249519 Pava MJ & Woodward JJ. A review of the interactions between alcohol and the endocannabinoid system: implications for alcohol dependence and future directions for research. Alcohol 46(3):185-204, 2012. PMCID: 3327810 Woodward JJ & Pava M. Ethanol inhibition of up-states in prefrontal cortical neurons expressing the genetically encoded calcium indicator GCaMP3. Alcoholism, Clinical and Experimental Research 36(5):780-787, 2012. PMCID: 3297730 Xu M, Smothers CT, Trudell JR & Woodward JJ. Ethanol inhibition of constitutively open N-methyl-d-aspartate receptors. Journal of Pharmacology and Experimental Therapeutics 340(1):218-226, 2012. PMCID: 3251024
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