Department of Ophthalmology

Peer-Reviewed Publications 2009-2014

Takahashi Y, Moiseyev G, Ablonczy Z, Chen Y, Crouch RK, and Ma JX. Identification of novel palmitylation site in RPE65 essential for its membrane association and isomerohydrolase activity. J Biol Chem 284:3211-3218, 2009, PMID: 19049981, PMCID: PMC2631947.

Thurman JM, Renner B, Kunchithapautham K, Ferreira VP, Pangburn MK, Ablonczy Z, Tomlinson S, Holers VM, and Rohrer B. Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. J Biol Chem 284:16939-16947, 2009, PMID: 19386604, PMCID: PMC2719331.

Ablonczy Z, Prakasam A, Fant J, Fauq A, Crosson CE, and Sambamurti K. Pigment epithelium-derived factor maintains RPE function by inhibiting VEGF-R2 signaling through the proteolytic action of γ-secretase. J Biol Chem 284: 30177-30186, 2009, PMID: 19723623, PMCID: PMC2781573.

Lara-Castillo N, Ahmed M, Noda K, Nakao S, She H, Frimmel S, Zandi S, Ablonczy Z, and Hafezi-Moghadam A. Atrial natriuretic peptide reduces vascular leakage and choroidal neovascularization. Am J Physiol 175:2343-2350, 2009, PMID: 19910509, PMCID: PMC2789643.

Prakasam A, Muthuswamy A, Ablonczy Z, Greig NH, Fauq A, Rao JK, Pappolla MA, and Sambamurti K. Differential accumulation of secreted AβPP metabolites in ocular fluids. J Alz Dis 20:1243-1253, 2010, PMID: 20413851.

Chinnakkannu P, Samanna V, Cheng G, Ablonczy Z, Baicu CF, Bethard JR, Menick DR, Kuppuswamy D, and Cooper 4th G. Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy. J Biol Chem 285:21837-21848, 2010, PMID: 20436166, PMCID: PMC22898445.

Gutierrez DB, Blakeley L, Goletz PW, Schey KL, Hanneken A, Koutalos Y, Crouch RK, and Ablonczy Z. Mass Spectrometry provides accurate and sensitive quantitation of A2E. Photochem Photobiol Sci 9:1513-1519, 2010, PMID: 20931136, PMCID: PMC3013054.

Truscott RJW, Comte-Walters S, Ablonczy Z, Schwacke JH, Berry Y, Korlimbinis A, Friedrich M, and Schey KL. Tight binding of proteins to membranes from older human cells. Age (Dordr) 33:543-554, 2010, PMID: 21181282.

Grey AC, Crouch RK, Koutalos Y, Schey KI, and Ablonczy Z. Spacial localization of A2E in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 52:3926-3933, 2011, PMID: 21357388, PMCID: PMC3175942.

Ablonczy Z, Liu Y, Dahrouj M, Tang PH, Sambamurti K, Marmorstein AD, and Crosson CE. Human retinal pigment epithelium cells as functional models for the RPE in vivo. Invest Ophthalmol Vis Sci 52:8614-8620, 2011, PMID: 21960553, PMCID: PMC3208409.

Ablonczy Z, Gutierrez DB, Grey AC, Schey KL, and Crouch RK. Molecule-specific imaging and quantitation of A2E in the RPE. Adv Exp Med Biol 723:75-81, 2012, PMID: 22183318.

Boyer NP, Higbee D, Currin MB, Blakeley LR, Chen C, Ablonczy Z, Crouch RK, and Koutalos Y. Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in the retinal pigment epithelium in the absence of light exposure: Their origin is 11-Cis retinal. J Biol Chem 22;287(26):22276-86, 2012, PMID: 22570475, PMCID: PMC3381188.

Boyer NP, Tang PH, Higbee D, Ablonczy Z, Crouch RK, and Koutalos Y. Lipofuscin and A2E Accumulate with Age in the Retinal Pigment Epithelium of Nrl(-/-) Mice(†). Photochem Photobiol 2012, PMID: 22417141, PMCID: PMC3381188.

Dahrouj M, Al Sarraf O, Liu Y, Crosson CE, and Ablonczy Z, C-type natriuretic peptide protects the retinal pigment epithelium against advanced glycation end-product-induced barrier dysfunction. JPET 344(1):96-102, 2013, PMID: 23086231, PMCID: PMC3533404.

Tang PH, Kono M, Koutalos Y, Ablonczy Z, Crouch RK: New insights into the retinoid metabolism and cycling within the retina. Prog Ret Eye Res 32:48-63, 2013, PMID: 23063666

Ablonczy Z, Higbee D, Anderson DM, Dahrouj M, Grey AC, Gutierrez DB, Koutalos Y, Schey KL, Hanneken A, Crouch RK: Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci, 54:5535-5542, 2013., PMID: 23847313, PMCID: PMC3747789

Kim JY, Zhao H, Martinez J, Doggett TA, Kolesnikov AV, Tang PH, Ablonczy Z, Chan CC, Zhou Z, Green DR, Ferguson TA: Non-canonical Autophagy Promotes the Visual Cycle. Cell, 154(2):365-76, 2013., PMID: 23870125, PMCID: 3744125

Ablonczy Z, Higbee D, Grey AC, Koutalos Y, Schey KL, Crouch RK: Similar molecules spatially correlate with lipofuscin and A2E in the mouse but not in the human RPE. Arch Biochem Biophys, 2013., PMID: 23969078

Dahrouj M, Al-Sarraf O, McMillin JC, Crosson CE, Ablonczy Z: VEGF modulates the hydraulic conductivity of the RPE in vivo. Invest Ophthalmol Vis Sci, 55:2269-2275, 2013., PMID: 24550368, PMCID: 3985404

Ablonczy Z, Smith N, Anderson DM, Grey AC, Spraggins J, Koutalos Y, Schey KL, Crouch RK:  The utilization of fluorescence to identify the components of lipofuscin by imaging mass spectrometry: Proteomics, 14:936-944, 2014., PMID: 24453194

Barnwell E, Padmaraju V, Baranello R, Pacheco-Quinto J, Crosson CE, Ablonczy Z, Eckman E, Eckman CB, Ramakrishnan V, Greig NH, Pappolla MA, Sambamurti K: Evidence of a novel mechanism for partial g-secretase inhibition induced paradoxical increase in secreted amyloid b protein. PLoS One 9:e91531, 2014., PMID: 24658363, PMCID: PMC3962361

Ablonczy Z, Dahrouj M, Marneros AG: Progressive dysfunction of the retinal pigment epithelium and retina due to increased VEGF-A levels. FASEB J, 28:2369-2379, 2014., PMID: 24558195, PMCID: PMC3986839

Anderson DMG, Ablonczy Z, Koutalos Y, Spraggins J, Crouch RK, Caprioli RM, Schey KL: High resolution 10µm MALDI imaging mass spectrometry of retinal tissue lipids. J Am Soc Mass Spectrom, 2014 (in press).

Sun D, Xie F, Nakao S, Zandi S, Bagheri A, Kanavi MR, Samiei S, Soheili ZS, Frimmel S, Ablonczy Z, Ahmadieh H, Hafezi-Moghadam A: Molecular imaging reveals elevated VEGFR-2 expression in retinal capillaries in diabetes: A biomarker for early diagnosis. FASEB J, 2014 (in press).

Ach T, Huisingh C, McGwin G, Messinger JD, Zhang T, Bentley MJ, Gutierrez DB, Ablonczy Z, Smith RT, Sloan KR, Curcio CA: Quantitative autofluorescence and cell density maps of the human retinal pigment epithelium. Ophthalmology, 2014 (submitted).

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