Jie Fan, Ph.D.
Principal Investigator, Jie Fan, Ph.D.
SUMMARY OF LABORATORY RESEARCH
I am the major participant in Dr. Craig Crosson’s research group which has direct implication in the understanding of glaucoma disease. Our research focuses on the role of protein acetylation and individual HDAC isoforms in the expression and secretion of inflammatory cytokines from optic nerve astrocytes. Understanding the cellular events that contribute to astrocyte activation will provide not only new insight into the pathogenesis of glaucoma, but also new strategies for treating this disease. Additionally, I will also focus and collaborate with other groups to investigate the roles of ceramide, which is the key mediator of cell stress responses and cell death, and its metabolism in retinal neuronal degeneration induced by retinal ischemia-reperfusion, which is used in the study of the transient ischemia-related diseases, such as glaucoma.