Department of Ophthalmology

Peer-Reviewed Publications 2007-2012

Ala-Laurila P, Kolesnikov AV, Crouch RK, Tsina E, Shukolyukov SA, Govardovskii VI, Koutalos Y, Wiggert B, Estevez ME, and Cornwall MC. Visual cycle: Dependence of retinol production and removal on photoproduct decay and cell morphology. J Gen Physiol 128:153-169, 2006; class="rprtid1"PMCID: PMC2151530.

Wu Q, Chen C, and Koutalos Y. Longitudinal diffusion of a polar tracer in the outer segments of rod photoreceptors from different species. Photochem Photobiol 82:1447-1451, 2006; PMID 16906792.

Wu Q, Chen C, and Koutalos Y. All-trans retinol in rod photoreceptor outer segments moves unrestrictedly by passive diffusion. Biophys J 91:4678-4689, 2006; class="rprtid1"PMCID: PMC1779927.

Wu, Q, Blakeley LR, Cornwall MC, Crouch RK, Wiggert BN, and Koutalos Y. Interphotoreceptor retinoid binding protein is the physiologically relevant carrier that removes retinol from rod photoreceptor outer segments. Biochemistry class="ti"46 class="ti":8669-8679, 2007; class="rprtid1"PMCID: PMC2568998.

Imanishi Y, Lodowski KH, and Koutalos Y. Two-photon microscopy: Shedding light on the chemistry of vision. Biochemistry 46:9674-9684, 2007; class="rprtid1"PMCID: PMC2718834.

Chen, C, Blakeley LR, and Koutalos Y. Formation of all-trans retinol after visual pigment bleaching in mouse photoreceptors. Invest Ophthalmol Vis Sci 50:3589-3595, 2009; class="rprtid1"PMCID: PMC2724838.

Koutalos Y. Measurement of the mobility of all-trans-retinol with two-photon fluorescence recovery after photobleaching. Methods Mol Biol 652:115-128, 2010; PMCID: PMC3025666.

Koutalos Y, and Cornwall MC. Microfluorometric measurement of the formation of all-trans-retinol in the outer segments of single isolated vertebrate photoreceptors. Methods Mol Biol 652:129-147, 2010; PMCID: PMC23010976.

Johnson D, Chen C, and Koutalos Y. 2-Hydroxypropyl-β-cyclodextrin removes all-trans retinol from frog rod photoreceptors in a concentration-dependent manner. J Ocul Pharmacol Ther 26: 245-258, 2010; PMCID: PMC22974852.

Gutierrez DB, Blakeley L, Goletz PW, Schey KL, Hanneken A, Koutalos Y, Crouch RK, and Ablonczy Z. Mass spectrometry provides accurate and sensitive quantitation of A2E. Photochem Photobiol Sci 9:1513-1519, 2010; PMCID: PMC3013054.

Chen C, and Koutalos Y. Rapid formation of all-trans retinol after bleaching in frog and mouse rod photoreceptor outer segments. Photochem Photobiol Sci 9:1475-1479, 2010; PMCID: PMC3013284.

Blue AV, Charles L, Howell D, Koutalos Y, Mitchum M, Nappi J, Zoller J. Introducing students to patient safety through an online interprofessional course. Adv Med Edu Pract 1:107-114, 2010.

Blakeley LR, Chen C, Chen CK, Chen J, Crouch RK, Travis GH, and Koutalos Y. Rod outer segment retinol formation is independent of Abca4, arrestin, rhodopsin kinase, and rhodopsin palmitylation. Invest Ophthalmol Vis Sci 52:3483-3491, 2011; PMCID: PMC3109038.

Grey AC, Crouch RK, Koutalos Y, Schey KI, and Ablonczy Z. Spacial localization of A2E in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 52:3926-3933, 2011; PMID: 21357388.

Boyer NP, Chen C, and Koutalos Y. Preparation of living isolated vertebrate photoreceptor cells for fluorescence imaging. J Vis Exp 52:(doi: 10.3791/2789), 2011; PMID: 21730941.

Chen C, Thompson DA, and Koutalos Y. Reduction of all-trans retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12. J Biol Chem 287:24662-24670, 2012; PMCID: PMC3397894.

Frederiksen R, Boyer NP, Nickle B, Chakrabarti KS, Koutalos Y, Crouch RK, Oprian D, and Cornwall MC. Low aqueous solubility of 11-cis retinal limits the rate of pigment formation and dark adaptation in salamander rods. J Gen Physiol 139:493-505, 2012; PMCID: PMC3362518.

Boyer NP, Higbee D, Currin MB, Blakeley LR, Chen C, Ablonczy Z, Crouch RK, and Koutalos Y. Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in the retinal pigment epithelium in the absence of light exposure: their origin is 11-cis retinal. J Biol Chem 287:22276-22286, 2012; PMCID: PMC3381188.

Boyer NP, Tang PH, Higbee D, Ablonczy Z, Crouch RK, and Koutalos Y. Lipofuscin and A2E accumulate with age in the retinal pigment epithelium of Nrl-/- mice. Photochem Photobiol (in press), 2012; PMID: 22417141.

Masutomi K. Chen C, Nakatani K, and Koutalos Y. All-trans retinal mediates light-induced oxidation in single living rod photoreceptors. Photochem Photobiol (in press), 2012; PMID: 22417174.

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