Department of Ophthalmology

Peer-Reviewed Publications 2009-2014

Chen, C, Blakeley LR, and Koutalos Y. Formation of all-trans retinol after visual pigment bleaching in mouse photoreceptors. Investigative Ophthalmology and Visual Science 50:3589-3595, 2009, PMID: 19264891, PMCID: PMC2724838.

Johnson D, Chen C, and Koutalos Y. 2-Hydroxypropyl-β-cyclodextrin removes all-trans retinol from frog rod photoreceptors in a concentration-dependent manner. J Ocul Pharmacol Ther 26: 245-258, 2010, PMID: 20565310, PMCID: PMC22974852.

Blue AV, Charles L, Howell D, Koutalos Y, Mitcham M, Nappi J, Zoller J.Introducing students to patient safety through an online interprofessional course. Adv Med Edu Pract 1:107-114, 2010

Koutalos Y, and Cornwall MC. Microfluorometric measurement of the formation of all-trans-retinol in the outer segments of single isolated vertebrate photoreceptors. Methods Mol Biol 652:129-147, 2010, PMID: 20552426, PMCID: PMC23010976.

Koutalos Y. Measurement of the mobility of all-trans-retinol with two-photon fluorescence recovery after photobleaching. Methods Mol Biol 652:115-128, 2010, PMID: 20552425, PMCID: PMC3025666.

Chen C, and Koutalos Y. Rapid formation of all-trans retinol after bleaching in frog and mouse rod photoreceptor outer segments. Photochem Photobiol Sci 9:1475-1479, 2010, PMID: 20697621, PMCID: PMC3013284.

Gutierrez DB, Blakeley L, Goletz PW, Schey KL, Hanneken A, Koutalos Y, Crouch RK, and Ablonczy Z. Mass spectrometry provides accurate and sensitive quantitation of A2E. Photochem Photobiol Sci 9:1513-1519, 2010, PMID: 20931136, PMCID: PMC3013054.

Blakeley LR, Chen C, Chen CK, Chen J, Crouch RK, Travis GH, and Koutalos Y. Rod outer segment retinol formation is independent of Abca4, arrestin, rhodopsin kinase, and rhodopsin palmitylation. Invest Ophthalmol Vis Sci 52:3483-3491, 2011, PMID: 21398289, PMCID: PMC3109038.

Grey AC, Crouch RK, Koutalos Y, Schey KI, and Ablonczy Z. Spacial localization of A2E in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 52:3926-3933, 2011, PMID: 21357388, PMCID: PMC3175942.

Boyer NP, Chen C, and Koutalos Y. Preparation of living isolated vertebrate photoreceptor cells for fluorescence imaging. J Vis Exp 52:<http://www.jove.com/details.php?id-2789>, 2011, PMID: 21730941.

Frederiksen R, Boyer NP, Nickle B, Chakrabarti KS, Koutalos Y, Crouch RK, Oprian D, and Cornwall MC. Low aqueous solubility of 11-cis-retinal limits the rate of pigment formation and dark adaptation in salamander rods. J Gen Physiol. 2012;139:493-505., PMID: 22641642, PMCID: PMC3362518

Chen C, Thompson DA, and Koutalos Y. Reduction of all-trans retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12. J Biol Chem. 287:24662–24670, 2012., PMID: 22621924, PMCID: PMC3397894

Masutomi K, Chen C, Nakatani K, and Koutalos Y, All-Trans Retinal Mediates Light-Induced Oxidation in Single Living Rod Photoreceptors(†). Photochem Photobiol. 2012., PMID: 22417174, PMCID: PMC3382005

Boyer NP, Tang PH, Higbee D, Ablonczy Z, Crouch RK, and Koutalos Y. Lipofuscin and A2E Accumulate with Age in the Retinal Pigment Epithelium of Nrl(-/-) Mice(†). Photochem Photobiol, 88:1373-1377, 2012, PMID: 22417141, PMCID: PMC3652668

Tang PH, Kono M, Koutalos Y, Ablonczy Z, Crouch RK.  New insights into retinoid metabolism and cycling within the retina. Prog Retin Eye Res 32:48-63, 2013., PMID: 23063666, PMCID: PMC3746031

Koutalos Y. Will the Rod Bend or Break? Analyzing the Structural Resilience of Cellular Organelles, Biophys J 104:284-285, 2013., PMID: 23442849, PMCID: PMC3552276

Ablonczy Z, Higbee D, Anderson DM, Dahrouj M, Grey AC, Gutierrez D, Koutalos Y, Schey KL, Hanneken A, Crouch RK. Lack of Correlation Between the Spatial Distribution of A2E and Lipofuscin Fluorescence in the Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci 54:5535-5542, 2013., PMID: 23847313, PMCID: PMC3747789

Ablonczy Z, Higbee D, Grey AC, Koutalos Y, Schey KL, Crouch RK. Similar molecules spatially correlate with lipofuscin and N-retinylidene-N-retinylethanolamine in the mouse but not in the human retinal pigment epithelium. Arch Biochem Biophys 539:196-202, 2013., PMID: 23969078, PMCID: PMC3818512

Adler L IV, Chen C, Koutalos Y.  Mitochondria contribute to NADPH generation in mouse rod photoreceptors. Journal of Biological Chemistry, 289:1519-1528, 2014.    , PMID: 24297174, PMCID: PMC3894333

Ablonczy Z, Smith N, Anderson DM, Grey AC, Spraggins J, Koutalos Y, Schey KL, Crouch RK. (2014). The utilization of fluorescence to identify the components of lipofuscin by imaging mass spectrometry. Proteomics 14:936-944, 2014., PMID: 24453194, PMCID: PMC4017854

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