Department of Ophthalmology

Peer-Reviewed Publications 2009-2014

Ho L, Witteman JCM, Rohrer B, Hofman A, de Jong PTVM, and Vingerling JR. Lipoprotein-associated phospholipase A2 and risk of age-related macular degeneration: The Rotterdam Study. Arch Ophthalmol 127:340-341. 2009, PMID: 19273805.

Thurman JM, Renner B, Kunchithapautham K, Ferreira VP, Pangburn MK, Ablonczy Z, Tomlinson S, Holers VM, and Rohrer B. Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. J Biol Chem 284:16939-16947, 2009, PMID: 19386604, PMCID: PMC2719331.

Rohrer B, Long Q, Coughlin B, Wilson RB, Huang Y, Qiao F, Tang PH, Kunchithapautham K, Gilkeson GS, and Tomlinson S. A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration. Invest Ophthalmol Vis Sci 50:3056-3064, 2009, PMID: 19264882, PMCID: PMC2908507.

Kunchithapautham K, Coughlin B, Crouch R, and Rohrer B. Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacement. Invest Ophthalmol Vis Sci 50:4858-4864, 2009, PMID: 19407011.

Fan J, Sakurai K, Chen C-K, Rohrer B, Wu BX, Yau K-W, Kefalov V, and Crouch RK. Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism. J Neurosci 30:2496-2503, 2010, PMID: 20164334, PMCID: PMC22849294.

Thurman JM, Renner B, Kunchithapautham K, Holers VM, and Rohrer B. Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion. Adv Exp Med Biol 664:151-158, 2010, PMID: 20238013.

Ogando DG, Dahlquist KD, Alizadeh M, Kunchithapautham K, Li J, Yu N, LaVail MM, Rohrer B, Vollrath D, and Danciger M. Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice. Mol Vis 16:1004-1018, 2010, PMID: 20577653, PMCID: PMC2890552.

Bandyopadhyay M, and Rohrer B. Photoreceptor structure and function is maintained in organotypic cultures of mouse retinas. Mol Vis 16:1178-1185, 2010, PMID: 20664685, PMCID: PMC2901185.

Richards AJ, Muller B, Shotwell M, Cowart LA, Rohrer B, and Lu X. Assessing the functional coherence of gene sets with metrics based on the gene ontology graph. Bioinformatics 26:i79-i87, 2010, PMID: 20529941, PMCID: PMC22881388.

Pang J, Boye SE, Lei B, Boye SL, Everhart D, Umino Y, Rohrer B, Alexander J, Li J, Dai X, Li Q, Chang B, Barlow R, Hauswirth WW. Self-complementary AAV-mediated gene therapy restores cone function and prevents cone degeneration in two models of RPE65 deficiency. Gene Ther 17:815-826, 2010, PMID: 20237510, PMCID: PMC3014850.

Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira VP, Pangburn MK, Gilkeson GS, Thurman JM, Tomlinson S, and Holers VM. A targeted inhibitor of the compliment alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. Adv Exp Med Biol 703:137-150, 2010, PMID: 20711712.

Chen YA, Almeida JS, Richards AJ, Müller P, Carroll RJ, Rohrer B. A nonparametric approach to detect nonlinear correlation in gene expression. J Comp Graph Stat 19:552-568, 2010, PMID: 20877445, PMCID: PMC2945392.

Li X, Li W, Dai X, Kong F, Zheng Q, Zhou X, Lü F, Chang B, Rohrer B, Hauswirth WW, Qu J, and Pang JJ. Gene therapy rescues cone structure and function in the 3-month-old rd12 mouse: A model for midcourse RPE65 Leber congenital amaurosis. Invest Ophthalmol Vis Sci 52:7-15, 2011, PMID: 21169527, PMCID: PMC3053305.

Boger HA, Mannangatti P, Samuvel DJ, Saylor AJ, Bender TS, McGinty JF, Fortress AM, Zaman V, Huang P, Middaugh LD, Randall PK, Jayanthi LD, Rohrer B, Helke KL, Granholm AC, and Ramamoorthy S. Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes Brain Behav 10:186-198, 2011, PMID: 20860702, PMCID: PMC3026906.

Rohrer B, Coughlin B, Kunchithapautham K, Long Q, Tomlinson S, Takahashi K, and Holers VM. The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization. Mol Immunol 48:e1-e8, 2011, PMID: 21257205, PMCID: PMC3063365.

Kunchithapautham K, Coughlin B, Lemasters JJ, and Rohrer B. Differential effects of rapamycin on rods and cones during light-induced stress in albino mice. Invest Ophthalmol Vis Sci 52:2967-2975, 2011, PMID: 21273550, PMCID: PMC3109010.

Granholm AC, Zaman V, Godbee J, Smith M, Ramadan R, Umphlet C, Randall P, Bhat NR, Rohrer B, Middaugh LD, and Boger HA. Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice. Brain Pathol 21:330-348, 2011, PMID: 20969653, PMCID: PMC3042034.

Smith AW, Das A, Guyton MK, Ray SK, Rohrer B, and Banik NL. Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis. Invest Ophthalmol Vis Sci 52:4935-4941, 2011, PMID: 21613375, PMCID: PMC3175948.

Potter KA, Kern MJ, Fullbright G, Bielawski J, Scherer SS, Yum SW, Li J, Cheng H, Han X, Venkata JK, Khan PAA, Rohrer B, and Hama H. Central nervous system dysfunction in a mouse model of FA2H deficiency. Glia 59:1009-1021, 2011, PMID: 21491498, PMCID: PMC3094470.

Kunchithapautham K, and Rohrer B. Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive VEGF secretion in retinal pigment epithelium monolayers. J. Biol. Chem. 286:23717-23724, 2011, PMID: 21566137, PMCID: PMC3129152.

Kunchithapautham K, Bandyopadhyay M, Dahrouj M, Thurman JM, and Rohrer B. Sublytic membrane-attack-complex activation and VEGF secretion in retinal pigment epithelial cells. Adv Exp Med Biol 723:23-30, 2012, PMID: 22183311.

Klionsky D, Abdalla FC, …., Rohrer B, .... , Zuckerbraun B. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8:445-544, 2012 , PMID: 22966490

Rohrer B, Coughlin B, Bandyopadhyay M, Holers VM. Systemic Human CR2-Targeted Complement Alternative Pathway Inhibitor Ameliorates Mouse Laser-Induced Choroidal Neovascularization. J Ocul Pharmacol Ther. 28:402-9, 2012  , PMID: 22309197, PMCID: PMC3406320

Richards AJ, Schwacke JH, Rohrer B, Cowart LA, Lu X. Revealing functionally coherent subsets using a spectral clustering and an information integration approach. BMC Syst Biol.;6 Suppl 3:S7, 2012    , PMID: 23282411, PMCID: PMC3542577

Perron NR, Beeson, CC, Rohrer B. Early alterations in mitochondrial reserve capacity: a means to predict disease pathogenesis and a method for screening protective agents. J Bioenerg Biomembr.  45:101-9, 2013, PMID: 23090843

Bandyopadhyay M, Kono M, Rohrer B.  Explant cultures of Rpe65-/- mouse retina, a model to investigate cone opsin trafficking. Mol Vis. 19:1149-1157, 2013   , PMID: 23734084, PMCID: PMC3669539

Joseph K, Kulik L, Coughlin B, Kunchithapautham K, Bandyopadhyay M, Thiel S, Thielens NM, Holers VM, Rohrer B. Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. J Biol Chem. 288:12753-65, 2013, PMID: 23493397, PMCID: PMC3642321

Thurman JM, Kulik L, Orth H, Wong M, Renner B, Sargsyan SA, Mitchell LM, Hourcade DE, Hannan JP, Kovacs JM, Coughlin B, Woodell AS, Pickering MC, Rohrer B, Holers VM. Detection of complement activation using monoclonal antibodies against C3d. J Clin Invest. 123:2218-30, 2013, PMID: 23619360, PMCID: PMC3635726

Whitcup SM, Sodhi A, Atkinson JP, Holers VM, Sinha D, Rohrer B, Dick AD. The role of the immune response in age-related macular degeneration. Int J Inflam, Article ID 348092, 2013    , PMID: 23762772, PMCID: 23762772

Woodell A, Coughlin B, Kunchithapautham K, Casey S, Williamson T, Ferrell WD, Atkinson C, Jones B, Rohrer B. Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury. PLOSone. 2013, 8:e67894. doi: 10.1371/journal.pone.0067894.    , PMID: 23825688, PMCID: PMC3692454

Smoke-exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation. Kunchithapautham K, Atkinson C, Rohrer B. J Biol Chem. 2014 Apr 7. [Epub ahead of print]

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