Department of Ophthalmology

Peer-Reviewed Publications 2007-2012

Rohrer B, Demos C, Frigg R, and Grimm C. Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse. Exp Eye Res 84:82-91, 2007; class="rprtid1"PMCID: PMC1885545.

Kunchithapautham K, and Rohrer B. Autophagy is one of the multiple mechanisms active in photoreceptor degeneration. Autophagy 3:65-66, 2007. PMID: 17102584.

Sharma AK, and Rohrer B. Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration. Curr Eye Res 32:259-269, 2007; PMID: 17453946.

Haq E, Rohrer B, Nath N, Crosson CE, and Singh I. S-nitrosoglutathione prevents interphotoreceptor retinoid-binding protein (IRBP161-180)-induced experimental autoimmune uveitis. class="ti"J Ocul Pharmacol Ther 23:221-231 class="ti", 2007; PMID: 17593005.

Wilson RB, Kunchithapautham K, and Rohrer B. Paradoxical role of BDNF: BDNF+/- retinas are protected against light damage-mediated stress. Invest Ophthalmol Vis Sci 48:2877-2886, 2007. class="rprtid1"PMCID: PMC1964504.

Kunchithapautham K, and Rohrer B. Apoptosis and autophagy in photoreceptors exposed to oxidative stress. Autopohagy, 3:433-441, 2007; PMID: 17471016.

Rohrer B, Guo Y, Kunchithapautham K, and Gilkeson GS. Eliminating complement factor D reduces photoreceptor susceptibility to light-induced damage. Invest Ophthalmol Vis Sci class="ti"48:5282-5289, 2007; PMID: 17962484.

Klionsky DJ, Abeliovich H, Agostinis P, ...Reggiori F, Rohrer B, Rubinsztein DC, ...Zhu X, and Deter RL. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, class="volume"4: class="pages"151-175, 2008; class="rprtid1"PMCID: PMC2654259.

Fan J, Rohrer B, Frederick JM, Baehr W, and Crouch RK. Rpe65-/- and Lrat-/- mice: Comparable models of Leber congenital amaurosis. Invest Ophthalmol Vis Sci class="volume"49: class="pages"2384-2389, 2008; class="rprtid1"PMCID: PMC2641010.

Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, and Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci 28:4008-4014, 2008; class="rprtid1"PMCID: PMC2562706.

Demos C, Bandyopadhyay M, and Rohrer B. Identification of candidate genes for human retinal degeneration loci using differentially-expressed genes from mouse photoreceptor dystrophy models. Mol Vis class="volume"14: class="pages"1639-1649, 2008; class="rprtid1"PMCID: PMC2529471.

Zaman V, Boger HA, Granholm AC, Rohrer B, Moore A, Buhusi M, Gerhardt GA, Hoffer BJ, and Middaugh LD. The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. Eur J Neurosci class="issue"8: class="pages"1557-1568, 2008; class="rprtid1"PMCID: PMC2704551.

Ho L, Witteman JCM, Rohrer B, Hofman A, de Jong PTVM, and Vingerling JR. Lipoprotein-associated phospholipase A2 and risk of age-related macular degeneration: The Rotterdam Study. Arch Ophthalmol 127:340-341. 2009; PMID: 19273805 class="rprtid1".

Rohrer B, Long Q, Coughlin B, Wilson RB, Huang Y, Qiao F, Tang PH, Kunchithapautham K, Gilkeson GS, and Tomlinson S. A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration. Invest Ophthalmol Vis Sci class="volume"50 class="ti2":3056-3064, 2009; class="rprtid1"PMCID: PMC2908507 class="rprtid1".

Kunchithapautham K, Coughlin B, Crouch R, and Rohrer B. Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacement. Invest Ophthalmol Vis Sci class="volume"50:4858-4864, 2009; PMID: 19407011 class="rprtid1".

Thurman JM, Renner B, Kunchithapautham K, Ferreira VP, Pangburn MK, Ablonczy Z, Tomlinson S, Holers VM, and Rohrer B. Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. J Biol Chem 284:16939-16947, 2009; class="rprtid1"PMCID: PMC2719331.

Fan J, Sakurai K, Chen C-K, Rohrer B, Wu BX, Yau K-W, Kefalov V, and Crouch RK. Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism. J Neurosci 30:2496-2503, 2010; class="rprtid1"PMCID: PMC22849294.

Thurman JM, Renner B, Kunchithapautham K, Holers VM, and Rohrer B. Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion. Adv Exp Med Biol 664:151-158, 2010; PMID: 20238013.

Pang J, Boye SE, Lei B, Boye SL, Everhart D, Umino Y, Rohrer B, Alexander J, Li J, Dai X, Li Q, Chang B, Barlow R, and Hauswirth WW. Self-complementary AAV-mediated gene therapy restores cone function and prevents cone degeneration in two models of Rpe65 deficiency. Gene Ther 17:815-826, 2010; class="rprtid1"PMCID: PMC3014850.

class="rprtid1"Bandyopadhyay M, and Rohrer B. Photoreceptor structure and function is maintained in organotypic cultures of mouse retinas. Mol Vis 16:1178-1185, 2010; PMCID: PMC2901185.

Richards AJ, Muller B, Shotwell M, Cowart LA, Rohrer B, and Lu X. Assessing the functional coherence of gene sets with metrics based on the gene ontology graph. Bioinformatics 26:i79-i87, 2010; PMCID: PMC22881388.

Ogando DG, Dahlquist KD, Alizadeh M, Kunchithapautham K, Li J, Yu N, LaVail MM, Rohrer B, Vollrath D, and Danciger M. Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice. Mol Vis 16:1004-1018, 2010; PMCID: PMC2890552.

Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira VP, Pangburn MK, Gilkeson GS, Thurman JM, Tomlinson S, and Holers VM. A targeted inhibitor of the compliment alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. Adv Exp Med Biol 703:137-149, 2010; PMID: 20711712.

Chen YA, Almeida JS, Richards AJ, Müller P, Carroll RJ, and Rohrer B. A nonparametric approach to detect nonlinear correlation in gene expression. J Comp Graph Stat 19:552-568, 2010; class="rprtid1"PMCID: PMC2945392.

Li X, Li W, Dai X, Kong F, Zheng Q, Zhou X, Lü F, Chang B, Rohrer B, Hauswirth WW, Qu J, and Pang JJ. Gene therapy rescues cone structure and function in the 3-month-old rd12 mouse: a model for midcourse RPE65 Leber congenital amaurosis. class="jrnl"Invest Ophthalmol Vis Sci class="src1" 52:7-15, 2011; class="rprtid1"PMCID: PMC3053305.

Boger HA, Mannangatti P, Samuvel DJ, Saylor AJ, Bender TS, McGinty JF, Fortress AM, Zaman V, Huang P, Middaugh LD, Randall PK, Jayanthi LD, Rohrer B, Helke KL, Granholm AC, and Ramamoorthy S. Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes Brain Behav 10:186-198, 2011; PMCID: PMC3026906.

Rohrer B, Coughlin B, Kunchithapautham K, Long Q, Tomlinson S, Takahashi K, and Holers VM. The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization. class="jrnl"Mol Immunol class="src1" 48:e1-e8, 2011; class="rprtid1"PMCID: PMC3063365.

Granholm AC, Zaman V, Godbee J, Smith M, Ramadan R, Umphlet C, Randall P, Bhat NR, Rohrer B, Middaugh LD, and Boger HA. Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice. Brain Pathol 21:330-348, 2011; PMCID: PMC3042034.

Kunchithapautham K, Coughlin B, Lemasters JJ, and Rohrer B. Differential effects of rapamycin on rods and cones during light-induced stress in albino mice. class="jrnl"Invest Ophthalmol Vis Sci class="src1" 52:2967-2975, 2011; class="rprtid1"PMCID: PMC3109010.

Potter KA, Kern MJ, Fullbright G, Bielawski J, Scherer SS, Yum SW, Li J, Cheng H, Han X, Venkata JK, Khan PAA, Rohrer B, and Hama H. Central nervous system dysfunction in a mouse model of FA2H deficiency. Glia 59:1009-1021, 2011; PMCID: PMC3094470.

Smith AW, Das A, Guyton MK, Ray SK, Rohrer B, and Banik NL. Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis. Invest Ophthalmol Vis Sci 52:4935-4941, 2011; PMCID: PMC3175948.

Kunchithapautham K, and Rohrer B. Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive VEGF secretion in retinal pigment epithelium monolayers. J Biol Chem 286:23717-23724, 2011; PMCID: PMC3129152.

Kunchithapautham K, Coughlin B, Lemasters JJ, and Rohrer B.  Differential effects of rapamycin on rods and cones during light-induced stress in albino mice.  class="jrnl"Invest Ophthalmol Vis Sci class="src1" 52:2967-2975, 2011; class="rprtid1"PMCID: PMC3109010.

Kunchithapautham K, Bandypadhyay M, Dahrouj M, Thurman JM, and Rohrer B.  Sublytic membrane-attack-complex activation and VEGF secretion in retinal pigment epithelial cells.  Adv. Exp. Med. Biol. 723:23-30, 2012; PMID: 22183311.

Bandyopadhyay M, and Rohrer B. Matrix metalloproteinase activity creates pro-angiogenic environment in primary human retinal pigment epithelial cells exposed to complement. Invest Ophthalmol Vis Sci 53:1953-1961, 2012; PMID: 22408008.

Rohrer B, Coughlin B, Bandyopadhyay M, and Holers VM. Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization. J Ocul Pharmacol 28:402-409, 2012; PMCID: PMC3406320.

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