Department of Ophthalmology

2012 Research Pictures

Dr. Ablonczy at the bench

Dr. Ablonczy is using reverse-transcriptase PCR to investigate how endogenous and environmental factors influence RPE function and contribute to the development and resolution of excess retinal fluid which is a common element in several retinal diseases such as diabetic retinopathy and AMD.

Dr. Crouch’s laboratory studies the role of vitamin A in the eye with an emphasis on the retina and retina pigment epithelium. These studies have important implications for AMD and other retinal degenerations that occur with aging.

Dr. Jie Fan uses cells cultured from the optic nerve to discover new insight into pathogenesis and treatment of glaucoma. Dr. Fan also studies the roles of lipids called ceramides in retinal neuronal degeneration.

Dr. Fields is studying cell transplantation as a promising therapeutic approach for the replacement of degenerated retinal cells in patients with AMD, retinitis pigmentosa, Stargardt’s disease and other retinal degenerations.

Dr. Husain performs enzyme immunoassays to identify factors that are responsible for optic nerve and retinal ganglion cells degeneration in ischemia and glaucoma and to develop neuroprotective strategies that delay (or prevent) vision loss in glaucoma.

Dr. Kono uses column chromatography to purify proteins and test their effects on cone cell survival, function, and opsin properties. The use of opsin inverse agonists may have broader applicability in improving photoreceptor survival for visual problems such as Leber Congenital Amaurosis type 2, Stargardt’s, retinitis pigmentosa, and aging.

Dr. Koutalos uses high-performance liquid chromatography (HPLC) to analyze the molecules required for the detection of light in the retina. These light sensitive molecules form toxic byproducts that lead to a variety of retinal diseases such as AMD and some forms of retinitis pigmentosa.

Using optical coherence tomography (OCT), Dr. Rohrer’s laboratory takes cross-sectional pictures of the retina and RPE of experimental animals to follow both the course of retinal degeneration as well as treatment outcomes.

 
 
 

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