Professor of Medicine
Dr. McDermott is a Professor of Medicine, Division of Cardiology, and Biochemistry and Molecular Biology. He received his Ph.D. in Anatomy and Cell Biology from the University of Pittsburgh School of Medicine. Dr. McDermott completed his postdoctoral training in the Dept. of Physiology at the Milton S. Hershey Medical Center, Penn State University and he received additional training as an Associate Scientist at the Weis Center for Research, Geisinger Clinic.
Dr. McDermott is a member of the American Heart Association , American Physiological Society, and the American Association for the Advancement of Science. Dr. McDermott currently serves on the NIH Study Section Cardiac Contractility, Hypertrophy and Failure. His service on MUSC committees include the Institutional Animal Care and Use Committee, the Graduate Curriculum Committee, and the Course Evaluation Subcommittee. Dr. McDermott is an Instructor in the Molecular Basis of Medicine course for medical students and the Foundations of Biomedical Sciences course for graduate students.
Dr. McDermott's research is focused on the regulation of protein synthesis during compensatory cardiac hypertrophy. Cardiovascular diseases such as systemic hypertension, valvular stenosis or insufficiency, and myocardial infarction cause hypertrophy and ultimately lead to congestive heart failure. Specifically, the role of translational mechanisms in regulating cardiac protein synthesis is being investigated. Gene transfer approaches are used to examine how changes in activity and/or amount of specific translation initiation factors control the expression of genes that are involved in hypertrophic growth and to determine whether these changes are linked to increased mechanical stress produced by hemodynamic overload. The goal of his research is to identify specific mechanisms in cardiac muscle cells that trigger abnormal cardiac growth.
Dr. Paul McDermott's Curriculum Vitae (PDF Format)*
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Paul J. McDermott, Ph.D.
Dr. McDermott's Research Interests
Regulation of cardiac protein synthesis
Control of gene expression in the heart
Protein metabolism during cardiac hypertrophy and failure