Division of endocrinology

Louis Luttrell, M.D., Ph.D.


Louis M. Luttrell earned his Bachelor of Arts degree in Zoology from Pomona College in 1979, where he graduated magna cum laude and was elected to the Phi Beta Kappa and Sigma Xi honor societies.  After spending a year on a Thomas J. Watson Foundation Fellowship for independent study abroad, he entered the Medical Scientist Training (M.D.-Ph.D.) Program at the University of Virginia in 1981.  His Doctor of Philosophy degree in Pharmacology was awarded in 1988 for work on the mechanism of insulin action conducted in the laboratory of Dr. Alan Rogol.  Dr. Luttrell received his Medical Doctorate in 1989 and was elected to the Alpha Omega Alpha honor society. He completed Internship and Residency in Internal Medicine at Duke University Medical Center between 1989 and 1992 and Fellowship in Endocrinology, Diabetes and Metabolism between 1992 and 1995.  His postdoctoral fellowship research on G protein-coupled receptor signaling was conducted in the laboratory of Dr. Robert J. Lefkowitz.  In 1995, Dr. Luttrell was awarded an NIH Clinical Investigator Development Award to study the role of heterotrimeric G proteins in the control of mitogenesis.  At that time, he joined the Duke University Department of Medicine faculty.  He was promoted to Assistant Professor of Medicine in 1998, to Associate Professor of Medicine in 2000, and was awarded tenure in 2003. During that time he developed an active NIH-funded research program focused on investigating novel mechanisms of G protein-coupled receptor signal transduction, crosstalk between G protein and tyrosine kinase signaling pathways, and the role of G protein-coupled receptor signals in the pathogenesis of cardiovascular and metabolic bone disease.  To date he has authored over 100 peer-reviewed scientific articles and six book chapters.  In 2003 his scientific contributions were recognized by election to the American Society for Clinical Investigation. Dr. Luttrell is ABIM certified in Internal Medicine and Endocrinology, Diabetes and Metabolism.  He joined the Department of Medicine at MUSC in 2003 as a Professor of Medicine and Director of the Division of Endocrinology, Diabetes and Medical Genetics.  In 2007 he was designated MUSC Eminent Scholar in Molecular and Cellular Endocrinology, and in 2009 was named holder of the James A. Keating, Jr. Endowed Chair in Diabetes.  Dr. Luttrell also serves as Director of the John A. Colwell Diabetes Research Center and Director of the MUSC Endocrinology Fellowship Training Program. He currently practices clinical endocrinology at Medical University Hospital and the Ralph H. Johnson VA Medical Center and participates in resident teaching in the outpatient clinic setting and on the inpatient General Internal Medicine service at the Charleston VA Medical Center.  He is Associate Program Director for the Medical Scientist Training Program at MUSC and participates in graduate student education in both the laboratory setting and as a graduate lecturer the MUSC College of Graduate Studies.  Outside of the University, Dr. Luttrell has served on numerous NIH study sections and is past chairperson of the Cellular Signaling and Dynamics study section.  He has served on the editorial board of The Journal of Biological Chemistry and is an Associate Editor of The Journal of Pharmacology and Experimental Therapeutics.    

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Louis M. Luttrell, M.D., Ph.D.

Dr. Luttrell's Clinical Interests

- General Endocrinology

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Selected Publications

View a partial list of Dr. Luttrell's publications through the National Library of Medicine's PubMed online database.

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