Division of infectious disease

John W. Gnann, Jr., MD

Dr. John Gnann, Professor of Medicine, joined the Division of Infectious Diseases at MUSC in 2013.

Dr. Gnann was born in Walterboro, South Carolina and grew up in Savannah, Georgia. He attended Davidson College (where he was elected to Phi Beta Kappa) and graduated from the Duke University School of Medicine. He moved to Alabama to complete a residency in Internal Medicine and a fellowship in adult Infectious Diseases at the University of Alabama at Birmingham (UAB).  After his training, Dr. Gnann joined the U.S. Army and served as Chief of the Infectious Diseases Service at Madigan Army Medical Center in Tacoma, Washington. Following his discharge from the Army, Dr. Gnann moved to California where he completed a three-year postdoctoral research fellowship in virology and immunology at the Research Institute of Scripps Clinic (La Jolla, California) in the laboratory of Michael B. A. Oldstone. In 1988, Dr. Gnann returned to Birmingham and joined the faculty of the Department of Medicine, Division of Infectious Diseases at UAB, rising to the rank of Professor of Medicine, Pediatrics, and Microbiology.

At UAB, Dr. Gnann was co-investigator of the NIAID-funded Collaborative Antiviral Study Group (along with Dr. Richard Whitley) for 20 years and provided leadership for multiple national and international studies of new antiviral therapies. Dr. Gnann also served for five years as the Medical Director of the UAB HIV care clinic, known as the 1917 Clinic.  He is a member of the CDC/NIH/IDSA Committee for Opportunistic Infections in HIV and served a 5-year assignment as a member of the NIAID study section for NIH grant reviews.  In 2013, Dr. Gnann moved to Charleston to join the Division of Infectious Diseases at the Medical University of South Carolina.

Dr. Gnann’s research interests are focused on viral infections and antiviral drugs. He has conducted extensive clinical research with investigational antiviral drugs directed against herpes viruses and respiratory viruses, including herpes simplex virus, varicella-zoster virus, cytomegalovirus, and influenza. These interests have also led to investigations of investigational therapies for hepatitis C virus and BK virus in solid organ transplant recipients. Dr. Gnann has also led investigations of viral encephalitis, including herpes simplex virus encephalitis and West Nile virus encephalitis. His group completed a large survey of the neurologic outcomes of West Nile virus during the recent outbreak in the United States.  Dr. Gnann has also been actively involved with human vaccine research and has been a principal investigator of clinical trials for varicella-zoster virus and anthrax vaccines. He has published over 75 peer-reviewed articles and over 50 chapters in major medical textbooks. 

Dr. Gnann’s clinical interests include management of opportunistic infections in immunocompromised patients, especially infections caused by viral pathogens. At MUSC, Dr. Gnann provides infectious diseases consultation in the hospital as well as outpatient care for a large population of patients with HIV infection.

Dr. Gnann is board-certified in Infectious Diseases and in Internal Medicine.  He is a Fellow of the American College of Physicians and of the Infectious Diseases Society of America.   

Dr. John Gnann's Curriculum Vitae (*PDF Format)

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John Gnann, M.D.
Dr. Gnann's Clinical Interests

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