Division of rheumatology & immunology

Cores and Funded Projects

Administrative Core

Gary Gilkeson, Director and Richard Silver, Associate Director

The Administrative Core provides leadership for the Center and support for the pilot projects. The core is responsible for the overall organization and operations of the MCRC.  Key roles of the core include leveraging resources, fostering productive interactions among investigators and trainees, and enhancing collaborations with other investigators in the field. 

Methodology Core

Paul Nietert, Director

The Methodology core helps the MCRC scientists with managing, analyzing, and reporting their data. They help the investigators make sure their study designs are optimal, and preform some of their own research to find new ways of handling large amounts of information from people's genes and their environments. 

Patient Resource Core

James Oates, PI

The Patient Resource Core serves the Projects and research base to accelerate translational research in scleroderma and lupus to increase knowledge of pathways of risk factors and triggers for these two devastating diseases that can be modified to improve and prevent these diseases.  Our community partnership increases the likelihood of translating findings to impact the community.

Project 1: Defective c- MET Signaling in African American Scleroderma Patients

Richard Silver and Galina Bogatkevich, MPIs

Interstitial lung disease (ILD) is a major complication and the leading cause of mortality in scleroderma with significantly higher morbidity and mortality rates in African American scleroderma patients.  The potential pathophysiologic links between the African American race and SSc-ILD are not identified.  Our goal is to fill in the gaps and identify casual factors that may account for the racial differences in SSc-ILD outcomes.  These studies are the first in the field of scleroderma research to provide genetic and mechanistic evidents underpinning the known health disparities in African American SSc patients.

Project 2: Genetic and Environmental Influences on SLE and Lupus- Related Autoimmunity

Gary Gilkeson and Diane Kamen, MPIs

Systemic lupus erythematosus (SLE) is a devastating disease primarily affecting younc African American women.  The cause of SLE is felt to be a combination of genetics and environmental exposures.  Determining these genetic and environmental factors will provide new understanding of SLE and perhaps lead to identification of preventative strategies and/or new therapies.  This project uses two unique cohorts, one from Africa and one from South Carolina, that are genetically and culturally linked yet differ significantly in envrionmental exposures.  Studies of these cohorts will lead to new understanding of the causes of SLE.

For more information please contact Gary Gilkeson (gilkeson@musc.edu).

 
 
 

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