Tamara Nowling, Ph.D.
Dr. Nowling earned her PhD at Iowa State University in Molecular, Cellular, and Developmental Biology and completed her post-doctoral training at the Eppley Cancer Institute of the University of Nebraska Medical Center. Dr. Nowling joined the faculty at the Medical University of South Carolina as a Research Assistant Professor in 2003. She is currently an Assistant Professor of Medicine in the Division of Rheumatology. As an expert in transcriptional gene regulation and expression, she has made significant contributions to several different fields of research including embryonic development, cancer and autoimmunity. She has obtained funding from NIH, Veterans Administration and the Alliance for Lupus Research Foundation and serves as a reviewer on study sections for the Arthritis Foundation and the Department of Defense. Dr. Nowling is a member of Sigma Xi Research Society, Arthritis Foundation, American Association of Immunologists, American College of Rheumatology and M.U.S.C.L.E. Research Group.
Dr. Nowling's current research program centers on understanding the regulatory mechanisms and role of molecules important in controlling the immune system and the progression of lupus nephritis. Her lab recently demonstrated that the transcription factor Fli1 plays a role in T cell function by mediating the glycosphingolipid metabolic pathway. Continuing studies include: 1) elucidating the precise mechanisms by which Fli1 mediates glycosphinogolipid metabolism in T cells; 2) the mechanism by which Fli1 regulates T cell function and the progression of disease; and 3) targeting the glycosphingolipid pathway as a therapeutic intervention in lupus nephritis. Her studies include analyses of mouse models of lupus and human lupus patient samples with a long-term goal of identifying therapeutic approaches and early markers of disease for early intervention in treating lupus patients. Additional collaborative projects in the lab include understanding the role of Vitamin D in maintaining telomere length to prevent premature cellular aging in lupus patients and evaluating the association between NMDA Receptor antibodies and neurocognitive dysfunction in pediatric lupus patients. All of the projects in her laboratory are highly collaborative with laboratories on campus and off and include both clinicians and bench scientists, including MUSC rheumatologists Drs. Gary Gilkeson, Jim Oates, Diane Kamen and Tasha Ruth and basic scientists Drs. John Zhang and Rick Drake.
Dr. Nowling has been actively involved as a lecturer for several graduate student courses and for Rheumatology fellows. She has mentored or co-mentored high school, undergraduate and graduate students, and post-doctoral fellows. She is very active in the MUSC Women Scholars Initiative, a Co-PI on an NSF ADVANCE grant to develop programs to support the advancement, recruitment and retention of women scientists (ARROWS) in the College of Medicine and a member of the Association for Women in Science.
Dr. Nowling's Curriculum Vitae (PDF Format)*
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